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Common Sickle Cell Treatment Safe for Babies.Avoiding Anemia: Boost Your Red Blood Cells.The findings could have implications for future therapeutic approaches. This work may lead to a better understanding of the spleen’s role in various disease states. “We have presented results showing that the spleen is the main organ that defines the shape of the circulating red blood cells,” Dao adds. “The computational and analytical models from this work, along with a variety of experimental observations, point to a more detailed picture of how the physiology of the human spleen likely influences several key geometrical characteristics of red blood cells,” Suresh says. The team’s predictions were consistent with independent experimental results using healthy, artificially modified, and infected human red blood cells. The work showed how the splenic slit determines the size and shape distributions of healthy red blood cells. The analyses revealed the limits of surface area and volume within which red blood cells can cross the spleen. Healthy red blood cells are disc-shaped and look like doughnuts without holes in the center. This is in contrast, they found, to the simple bullet-shaped deformation that occurs in narrow blood capillaries. The researchers determined that cells deform significantly as they cross the narrow splenic slit. The team developed computational simulations of the mechanics of red blood cells as they pass through the spleen.
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The study was published online in Proceedings of the National Academy of Sciences on June 27, 2016. Their work was funded in part by NIH’s National Heart, Lung, and Blood Institute (NHLBI). Ming Dao at MIT approached the problem by using computational simulation tools. Subra Suresh at Carnegie Mellon University and Dr. And invasive procedures, such as a biopsy or needle aspiration, can cause dangerous bleeding. The anatomy and physiology of the human spleen differ from that of common laboratory animal models. Studying how the human spleen filters faulty red blood cells has been challenging. In addition, some diseases - such as malaria, leukemia, and lymphomas - may cause enlargement of the spleen and lead it to filter out not only abnormal cells but also healthy red blood cells. Under certain conditions, such as hereditary spherocytosis, misshapen red blood cells can get trapped in the spleen, leading to anemia. When the red blood cells’ size, shape, or ability to deform is altered, they can’t pass through. They can only reenter the bloodstream if they’re able to pass through a tiny splenic structure called the interendothelial slit. These disc-shaped cells are filtered by the spleen based on their physical characteristics. Red blood cells carry oxygen throughout the body and remove carbon dioxide (a waste product). The spleen also removes unhealthy, old, and misshapen red blood cells from circulation. It holds key components of the body’s immune system. The spleen helps keep harmful microorganisms out of the bloodstream. It removes unhealthy, old, and misshapen red blood cells from circulation. The spleen is located under the rib cage.